Not really sure what to make of it, but it looks interesting -Clarisse is a new breed of high-end 2D/3D animation software that reinvents the traditional approaches of creating final images. In a single integrated application, Clarisse provides you with all the means to paint, animate, texture, surface, create layers, render and compose.
http://isotropix.com/clarisse.html
Commercially available sometime in 2011
Pricing: "expect a 4 digit number"